A tractor-trailer hauling dog food was heading east on I-76 when it attempted to take Exit 257 - Harrisburg East Interchange to I-283 Northbound, according to PennDOT and Turnpike officials.
That's when it flipped over — spilling dog food on the interstate at 1:47 a.m.
The exit ramp was fully closed until around 9 a.m. when one lane reopened, as seen on traffic cameras, but a second crash happened at 1:12 p.m. closing the ramp again.
Crews remained on the scene for clean up as of 2:30 p.m.
It is unclear when the roadway will fully reopen.
No injuries have been reported.
Click here to read about the other crash.
Click here to follow Daily Voice Phoenixville and receive free news updates.